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Headshot of Dr. Michael Taylor.

Michael D. Taylor

Title: Adjunct Scientist
Designations: MD, PhD, FRCS(C)
Email: mdtaylor@sickkids.ca
Alternate Contact Name: Seetha Sriharan
Alternate Phone: 416-813-6125 ext. 206125
Alternate Email: seetha.sriharan@sickkids.ca

Research Positions

Adjunct Scientist
Developmental and Stem Cell Biology

Biography

Born and raised in Canada, Dr. Taylor attended The University of Western Ontario and earned his medical degree in 1994. His education and training continued at the University of Toronto, where he earned his PhD in Molecular Genetics in 2002, and his residency training in Neurosurgery in 2003. Dr. Taylor then won a Detweiler Traveling Fellowship from the Royal College of Physicians and Surgeons of Canada for fellowship training in paediatric neurosurgery and paediatric neuro-oncology at St. Jude Children’s Research Hospital in Memphis, where he completed a post-doctoral fellowship in Cancer Genomics in the Department of Developmental Neurobiology.

Dr. Taylor is an Adjunct Scientist at SickKids. He is also a Paediatric Neurosurgeon and Scientist at the Baylor College of Medicine affiliated Texas Children’s Hospital. His laboratory is now located in Houston, Texas where he is a Professor, Department of Pediatrics – Hematology/Oncology and Neurosurgery, Baylor College of Medicine and Director, Pediatric Neuro-Oncology Research Program. His research centres on the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant paediatric brain tumours.

Research

The Taylor Lab’s research centres on the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant paediatric brain tumours. 

Education and experience

  • 1994: Medicine (cum laude) MD, University of Western Ontario, London, Ontario
  • 2003: FRCS Neurosurgery, University of Toronto, Ontario
  • 2002: PhD, Molecular Genetics of Paediatric Brain Tumours, University of Toronto, Ontario
  • 2003–2004: Post-Doc, Cancer Genomics, St. Jude Children’s Research Hospital, Memphis, Tennessee
  • 2004–2005: Post Doc, Functional Genomics, University of Toronto, Ontario
  • 2004–2022: Staff Neurosurgeon, The Hospital for Sick Children
  • 2004–2010: Assistant Professor, Department of Surgery, University of Toronto
  • 2004–2012: Scientist, Program in Developmental Biology, The Hospital for Sick Children
  • 2010–2013: Associate Professor, Department of Surgery, University of Toronto
  • 2012–2022: Senior Scientist, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
  • 2013–Present: Professor, Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto
  • 2023–Present: Adjunct Scientist, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
  • 2023–Present: Professor, Department of Pediatrics – Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, Texas
  • 2023–Present: Director, Pediatric Neuro-Oncology Research Program at Texas Children’s Hospital (TCH), Houston, TX

Achievements

  • 2008: Canada’s Top 40 under 40 award
  • 2009: Canadian Cancer Society Award. Young Investigator Award in Biomedical Science
  • 2010: Royal College of Physicians and Surgeons of Canada Gold Medal Award in Surgery
  • 2010: Canadian Institute of Health Research, Clinician-Scientist Award, Phase II - Renewal
  • 2011: George-Armstrong Peters Prize in Surgery, University of Toronto
  • 2013: Garron Family Endowed Chair in Childhood Cancer Research, Hospital for Sick Children
  • 2015: Canadian Cancer Society William E. Rawls Prize for 2015
  • 2016: Lister Prize in Surgery. University of Toronto 2016
  • 2016: Voynick Award in Neuro-Oncology 2016. Yale University
  • 2016: Guha Award in Neuro-Oncology 2016. Society for Neuro-Oncology
  • 2016: Zulch Prize in Basic Neuroscience 2016. Max Planck Society
  • 2019: H. Richard Winn, MD Prize. The Society of Neurological Surgeons
  • 2019: The Distinguished Oliver Smithies Lecture. McLaughlin Centre of the University of Toronto
  • 2019: Fellow and Member of the Royal Society of Canada
  • 2021: AACR Team Science Award (Team Co-Leaders: Crystal L. Mackall and John M. Maris, MDT one of ten principal investigators on the team)
  • 2021: 49th Fondation ARC Leopold Griffuel Award (co-awarded with Professor Stefan Pfister, Heidelberg)
  • 2021: Robert L. Noble Prize. Canadian Cancer Society (CCS) Award for Excellence in Cancer Research

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Publications

  1. Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. Cell. 2020 Jun 11;181(6):1329-1345.e24. doi: 10.1016/j.cell.2020.04.047. Epub 2020 May 22. PMID: 32445698
  2. Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nat Med. 2020 Apr 27. doi: 10.1038/s41591-020-0827-2. [Epub ahead of print]. PMID: 32341580 
  3. Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma. Nature. 2019 Oct 9. doi: 10.1038/s41586-019-1650-0. [Epub ahead of print] PMID: 31597162.
  4. The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature. 2019 Oct;574(7780):712-716. doi: 10.1038/s41586-019-1651-z. Epub 2019 Oct 9. PMID: 31597163. 
  5. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019 Aug;572(7767):67-73. doi: 10.1038/s41586-019-1158-7. Epub 2019 May 1. PMID: 31043743. 

See a full list of Michael Taylor's publications

  • SickKids Foundation
  • Garron Family Foundation
  • Rally Foundation
  • Swifty Foundation
  • V-Foundation
  • Meagan’s Walk
  • b.r.a.i.nchild
  • Canadian Cancer Society Research Institute
  • Genome Canada
  • Genome BC
  • Genome Quebec
  • Stand Up to Cancer (US and Canada)
  • CIHR
  • OICR
  • NIH
  • Ontario Research Fund
  • Cancer Research UK
  • IronMatt
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