Blayne Amir Sayed

Title: Staff Surgeon, Division of General & Thoracic Surgery

Designations: MD, PhD

Phone: 416-813-7654 ext. 206401

Fax: 416-813-7477

Alternate Contact Name: Shannon Hannah

Alternate Phone: 416-813-7654 ext. 206401

Alternate Email: shannon.hannah@sickkids.ca

U of T Positions: Assistant Professor, Department of Surgery

Research Positions

Associate Scientist Track
Cell Biology

Biography

Dr. Sayed is a member of the Division of General & Thoracic Surgery at SickKids. He specializes in malignant and benign diseases of the liver and biliary tract. Dr. Sayed is dually certified in hepatopancreatobiliary surgery and abdominal organ transplantation with particular interests in minimally invasive liver surgery, living donor liver transplantation and complex liver surgery involving vascular and biliary reconstruction. Dr. Sayed is an Associate Scientist Track with a background in cellular immunology. He is building a lab focused on understanding the molecular machinery controlling the development of immunologic memory following solid organ transplantation.

Research

Dr. Sayed is an Associate Scientist Track with a background in cellular immunology. His research is focused on understanding the molecular machinery controlling the development of allo-immunity following solid organ transplantation. This includes an interest in the epigenetic mechanisms of memory formation in cells of both the adaptive and innate immune systems. Dr. Sayed is a member of the Cell Biology program and his mentor is Dr. Sergio Grinstein.

Education and experience

2017–2019: Clinical Fellow, Abdominal Organ Transplantation and Hepatopancreatobiliary Surgery, Department of Surgery, University of Toronto, Toronto, ON CA
2016–2017: Administrative Chief Resident, Department of Surgery, Emory University School of Medicine, Atlanta, GA
2014–2015: Clinical Fellow, Liver Transplant Unit and Liver Sciences Institute, King’s College Hospital and King’s College London, London, U.K.
2011–2017: General Surgery Resident, Department of Surgery, Emory University School of Medicine, Atlanta, GA
2002–2011: NIH Medical Scientist Training Program (MSTP), Northwestern University Feinberg School of Medicine, Chicago, IL
2011: MD, Northwestern University Feinberg School of Medicine, Chicago, IL
2009: PhD, Integrated Graduate Program (IGP), Department of Microbiology & Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL
1998-2001: BA with distinction, University of Virginia, Charlottesville, VA

Achievements

2019: American Society of Transplantation (AST) Liver & Intestinal Community of Practice (LICOP) Travel Award, American Transplant Congress, Boston MA
2017: Douglas A Murray Professionalism in Surgery Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
2017: David V Feliciano Resident Excellence in Teaching Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
2016–2017: Administrative Chief Resident (elect), Department of Surgery, Emory University School of Medicine, Atlanta, GA
2014: J.D. Martin Surgical Resident Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
2010: Alpha Omega Alpha (AOA) Honor Medical Society, Gamma Illinois Chapter, Feinberg School of Medicine, Northwestern University, Chicago, IL.
2009–2010: Alliance for Graduate Education and the Professoriate (AGEP) Scholar, The Graduate School, Northwestern University, Evanston, IL.
2009–2010: Herbert W. Nickens Medical Student Award, Association of American Medical Colleges (AAMC), Washington, DC.

Publications

Sayed BA, Boster JM, Superina R, Mazariegos GV, et al. Predictors of survival following liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma: Experience from the Society of Pediatric Liver Transplantation (SPLIT). Am J Transplant. 2022;22(5):1396-1408. doi:10.1111/ajt.16945
Patel MS, Ghanekar A, Sayed BA, et al. Liver Retransplantation Using Living Donor Grafts: A Western Experience. Liver Transpl. 2022;28(5):887-890. doi:10.1002/lt.26314
Malkiel S, Sayed BA, Ng V, et al. Sequential paternal haploidentical donor liver and HSCT in EPP allow discontinuation of immunosuppression post-organ transplant. Pediatr Transplant. 2021;25(6):e14040. doi:10.1111/petr.14040
Arias GA, Siddiqui I, Navarro OM, Shaikh F, Sayed BA, Chavhan GB. Imaging and clinical features of pediatric hepatocellular carcinoma. Pediatr Radiol. 2021;51(8):1339-1347. doi:10.1007/s00247-021-04989-x
Xu J, Sayed BA, Casas-Ferreira AM, et al. The Impact of Ischemia/Reperfusion Injury on Liver Allografts from Deceased after Cardiac Death versus Deceased after Brain Death Donors. PLoS One. 2016;11(2):e0148815. Published 2016 Feb 10. doi:10.1371/journal.pone.0148815

2020–2021: HSBC Catalyst Research Grant, SickKids. Personalized physiologic phenotyping in the ICU to predict clinical outcomes in liver transplant patients. Co-investigator
2015–2017: Translational Science Fellowship Research Grant, American Society of Transplantation (AST). Epigenetic regulation of CTLA-4 modifies susceptibility to the development of pathogenic T cells mediating a belatacept resistant alloreactive immune response Principal Investigator
2011: Genentech Presidential Student Mentorship Grant, American Society of Transplant Surgeons.The role of short lived effector cells (SLEC) in the alloimmune response. Principal Investigator
2005–2010: Kirschtein National Research Service Award (NRSA), Individual Pre-doctoral Fellowship: Blayne Amir Sayed. Natl. Inst. for Neurological Disease and Stroke (NINDS), NIH: F31 NS054395-01.The role of mast cells in a model of relapsing remitting multiple sclerosis. Principal Investigator