Jeehye Park

Dr. Jeehye Park received her PhD from Jongkyeong Chung lab at Korea Advanced Institute of Science and Technology (Daejeon, South Korea), where she studied the molecular mechanism of Parkinson’s disease. She completed postdoctoral training in Huda Zoghbi lab at Baylor College of Medicine (Houston, USA) and studied spinocerebellar ataxia type 1.

Research

Dr. Park’s lab's current focus is investigating the molecular pathogenesis of a neurodegenerative disease called amyotrophic lateral sclerosis (ALS) and identify therapeutic targets to develop treatments for ALS patients. Mutations within RNA binding protein (RBP)-encoding genes have been implicated in ALS, but how mutations in RBPs lead to motor neuron degeneration is not clear.

Her lab studies one of the under-characterized RBPs called Matrin3 (MATR3) involved in RNA splicing and is investigating how ALS-linked mutations alter the function of MATR3 and cause motor neuron degeneration. The research team is is using an interdisciplinary approach by combining biochemistry, molecular and cellular biology, fruit fly and mouse genetics, high-throughput forward genetic screens and whole transcriptome analysis.

Education and experience

• 2023–Present: Associate Professor, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON
• 2022–Present: Senior Scientist, Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON
• 2016–2023: Assistant Professor, Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON
• 2015–2022: Scientist, Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON
• 2008–2015: Postdoc, Department of Molecular and Human Genetics, Baylor College of Medicine, USA
• 2004–2008: Doctorate, PhD, Department of Biological Sciences, Korea Adv Inst of Sci and Tech, Korea

Achievements

• 2016: Canada Research Chair (Tier 2) in Molecular Genetics and Neurodegenerative Diseases, Canada Research Chairs Program
• 2014: Best Paper Award, Dept. of Molecular and Human Genetics, Baylor College of Medicine, USA
• 2013: Keystone Symposia Scholarship Santa Fe, New Mexico, USA
• 2007: Outstanding Research Award Department of Biological Sciences, KAIST, Daejeon, South Korea
• 2006: UNESCO-L'OREAL Co-Sponsored Fellowships for Young Women in Life Sciences, Seoul, South Korea

1. Santos J. R. & Park J#. MATR3's Role beyond the Nuclear Matrix: From Gene Regulation to Its Implications in Amyotrophic Lateral Sclerosis and Other Diseases. Cells (2024). DOI: 3390/cells13110980. PMID: 38891112; PMCID: PMC11171696. (#: corresponding author)
2. Khan M.*, Chen X. X. L.*, Dias M.*, Santos J. R.*, Kour S., You J., Youssef M., van Bruggen R., Liu Z., Pandey U. B., Rosenfeld J. A., Tan Q., Yalamanchili H. K.#, Park J#. MATR3 pathogenic variants differentially impair its cryptic splicing repression function. FEBS Letters. (2024). DOI: 10.1002/1873-3468.14806 (*: co-first authors, #: co-corresponding authors)
3. You J.*, Maksimovic K.*, Lee J., Khan M., Masuda R. & Park J#. Selective loss of MATR3 in spinal interneurons, corticospinal motor neurons and hippocampal neurons in a MATR3 S85C knock-in mouse model of amyotrophic lateral sclerosis. Biology (2022) 11(2), 298. DOI: 10.3390/biology11020298 (*: co-first authors, #: corresponding author)
4. Kao C. S.*, van Bruggen R.*, Kim J. R.*, Chen X. X. L.*, Chan C., Lee J., Cho W. I., Zhao M., Arndt C., Maksimovic K., Khan M., Tan Q., Wilson M. D. & Park J#. Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early stage of ALS. Nature Communications (2020) 11, 5304. DOI: 10.1038/s41467-020-18949-w. PMID: 33082323 (*: co-first authors, #: corresponding author)
5. Zhao M.*, Kao C. S.*, Arndt C., Tran D.D., Cho W. I., Maksimovic K., Chen X. X. L., Khan M., Zhu H., Qiao J., Peng K., Hong J., Xu J., Kim D., Kim J. R., Lee J., van Bruggen R., Yoon W.H. & Park, J#. Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease‐linked MATR3 mutations in Drosophila. FEBS Letters (2020) 594, 2800-2818. DOI: 10.1002/1873-3468.13858. PMID: 32515490 (*: co-first authors, #: corresponding author)

See a full list of Dr. Jeehye Park's publications on Pubmed and Google Scholar. 

Funding

• 2024–2025: Investigation of the role of disease-associated microglia (DAM) in ALS pathogenesis, PI, Frick Foundation for ALS Research, $150,000 CAD
• 2023–2024: Evaluation of metabolic interventions for ALS prevention, Co-PI (With Dr. Hoon-Ki Sung) , ALS Association (Prevention Grant Program), $548,000 CAD
• 2021–2026: Determining the mechanism underlying selective neuronal vulnerability in ALS, PI, Canadian Institutes of Health Research (CIHR) (Project Grant), $952,426 CAD
• 2018–2025: Control of gene expression during neuronal development, PI, NSERC (Discovery grant), $185,000 CAD