Seema Mital

Dr. Seema Mital completed her paediatric residency at Children’s Hospital of Michigan in 1996 and a fellowship in Paediatric Cardiology in 1999 from Columbia University, New York, USA. Mital was Assistant Professor at Columbia University, Morgan-Stanley Children’s Hospital of New York, until 2007 when she joined SickKids as a Staff Cardiologist in the Heart Function and Transplant Program.

Research

Dr. Mital leads the Cardiac Precision Medicine Program at SickKids, that leverages genomics, stem cells, AI and digital technology to model disease, test therapies, and implement precision-focussed decision support tools. Dr. Mital established the SickKids Heart Centre Biobank, a multi-centre biorepository for childhood onset heart disease, one of the largest international repositories of its kind. She leads the ERAPerMed/CIHR funded PROCEED network for Personalized Genomics in congenital heart disease, the multi-centre international Precision Medicine in Cardiomyopathy (PRIMaCY) network, the multi-centre CIHR-funded INSERT-HCM study, and co-leads the CIHR-funded Precision Medicine for Heart Failure in the Young (PRIORITY) project of the Canadian Heart Function Alliance. Dr. Mital serves on the Executive Committee of the Ted Rogers Centre for Heart Research, the Canadian Heart Function Alliance, and Precision Child Health Sequencing (PCHSeq) study. She is Associate Editor for the journal Circulation.

Education and experience

• 1996–1999: Fellowship, Paediatric Cardiology, Columbia University, New York, NY, USA
• 1995–1996: Research Fellowship, Neonatology, Children’s Hospital of Michigan, Detroit, MI, USA
• 1993–1996: Residency, Paediatrics, Children’s Hospital of Michigan, Wayne State University, Detroit, MI, USA

Achievements

• 2014-2029: Heart and Stroke Foundation of Canada / Robert M. Freedom Chair in Cardiovascular Science
• 2025: Best Cardiovascular Science of the Decade Award (Clinical Science), Top 5 finalist, Ted Rogers Centre for Heart Research, Toronto, Ontario, Canada
• 2022: Faculty Recognition Award for Strong Citizenship, Institute of Medical Science, University of Toronto
• 2020: Co-recipient, Janet Rossant Research Innovation Prize for Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation

1. Rossano J, Canter C, Wolf C, Papez A, Gambra M, Bryant R, Alejos J, McCulloch M, Brugada GS, Bock MJ, Jeewa A, Pearce B, Desai M, Favatella N, Javidialsaadi A, Phung V, Rano T, Zhu L, Dyme J, Mital S, on behalf of the SCOUT-HCM investigators. Mavacamten in adolescents with symptomatic obstructive hypertrophic cardiomyopathy: primary results from SCOUT-HCM. The New England Journal of Medicine. 2026 Jul 23; 395(4): pp 362-373.
2. Turinsky A, Hanafi N, Said A, Lesurf R, López-Guillén JL, Akilen R, Kinnear C, Frayne IR, Ellis J, Mertens L, Ruiz M, Mital S. Abnormal lipid signaling characterizes diastolic dysfunction in pediatric cardiomyopathy. Journal of the American College of Cardiology: Basic to Translational Science 2026 Mar: 11(3); pp 101491
3. Lesurf R, Breckpot J, Bouwmeester J, Hanafi N, Jain A, Liang Y, Papaz T, Lougheed J, Mondal T, Alsalehi M, Altamirano-Diaz L, Oechslin E, Audain E, Dombrowsky G, Postma AV, Woudstra OI, Bouma BJ, Hitz M-P, Bezzina CR, Blue G, Winlaw DS, Mital S. A validated heart-specific model for splice-disrupting variants in childhood heart disease. Genome Medicine. 2024 Oct 15; 16(1): pp 119.
4. Miron A, Lafreniere-Roula M, Fan CP, Armstrong K, Dragulescu A, Papaz T, Manlhiot C, Kaufman B, Butts R, Gardin L, Stephenson E, Howard T, Aziz P, Balaji S, Beauséjour –Ladouceur V, Benson L, Colan S, Godown J, Henderson H, Ingles J, Jeewa A, Jefferies J, Lal A, Mathew J, Jean-St-Michel E, Michels M, Nakano S, Olivotto I, Parent J, Pereira A, Semsarian C, Whitehill R, Wittekind S, Russell M, Conway J, Richmond M, Villa C, Weintraub R, Rossano J, Kantor P,Y. Ho C, Mital S. A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy. Circulation. 2020: 142 (3): pp 217–229. 
5. Ommen SR, Mital S (Vice-Chair), Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2020: 76 (25): pp e159 – e240. (Dec)

View a full list of Seema Mital's publications in PubMed

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