Seema Mital
Research Positions
Biography
Dr. Seema Mital completed her paediatric residency at Children’s Hospital of Michigan in 1996 and a fellowship in Paediatric Cardiology in 1999 from Columbia University, New York, USA. Mital was Assistant Professor at Columbia University, Morgan-Stanley Children’s Hospital of New York, until 2007 when she joined SickKids as a Staff Cardiologist in the Heart Function and Transplant Program.
Dr. Mital serves on the executive committees of the SickKids Labatt Family Heart Centre, the Heart and Stroke Richard Lewar Centre of Excellence, the Ted Rogers Centre for Heart Research, and the Canadian Heart Function Alliance. She is also a fellow of the American Heart Association and serves on the Scientific Publications Committee, as well as the Strategic Outcomes Committee.
Research
Dr. Mital is the Head of Cardiovascular Research at SickKids and Senior Scientist at the SickKids Research Institute. She is also the Heart and Stroke Foundation of Canada Chair of Cardiovascular Science and the Scientific Co-Lead of the Ted Rogers Centre for Heart Research. Dr. Mital leads the Cardiac Precision Medicine Program at SickKids, that leverages genomics, stem cells, AI and digital technology to model disease, test therapies, and implement precision-focussed decision support tools. Dr. Mital established the SickKids Heart Centre Biobank, a multi-centre biorepository for childhood onset heart disease, one of the largest international repositories of its kind. She leads the ERAPerMed/CIHR funded PROCEED network for Personalized Genomics in congenital heart disease, the multi-centre international Precision Medicine in Cardiomyopathy (PRIMaCY) network, the multi-centre CIHR-funded INSERT-HCM study, and co-leads the CIHR-funded Precision Medicine for Heart Failure in the Young (PRIORITY) project of the Canadian Heart Function Alliance.
Education and experience
- 1996–1999: Fellowship, Paediatric Cardiology, Columbia University, New York, NY, USA
- 1995–1996: Research Fellowship, Neonatology, Children’s Hospital of Michigan, Detroit, MI, USA
- 1993–1996: Residency, Paediatrics, Children’s Hospital of Michigan, Wayne State University, Detroit, MI, USA
Achievements
- 2022: Faculty Recognition Award for Strong Citizenship, Insitute of Medical Science, University of Toronto
- 2020: Co-recipient, Janet Rossant Research Innovation Prize for Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation
Publications
- Lesurf R*, Said A*, Akinrinade O, Breckpot J*, Delflosse K, Liu T, Yao R, Persad G, McKenna F, Noche RR, Oliveros W, Mattioli K, Shah S, Miron A, Yang Q, Meng G, Yue MCS, Sung WWL, Thiruvahindrapuram B, Lougheed J, Oechslin E, Mondal T, Bergin L, Smythe J, Jayappa S, Rao VJ, Shenthar J, Dhandapany PS, Semsarian C, Weintraub RR, Bagnall RD, Ingles J, Genomics England Research Consortium, Mele M, Maass PG, Ellis J, Scherer SW, Mital S. Whole genome sequencing delineates regulatory, copy number and cryptic splice variants in early onset cardiomyopathy. (*co-first authors). Nature Portfolio Journal Genomic Medicine. 2022: 7 (1): pp 18. (Mar).
- Miron A, Lafreniere-Roula M, Fan CP, Armstrong K, Dragulescu A, Papaz T, Manlhiot C, Kaufman B, Butts R, Gardin L, Stephenson E, Howard T, Aziz P, Balaji S, Beauséjour –Ladouceur V, Benson L, Colan S, Godown J, Henderson H, Ingles J, Jeewa A, Jefferies J, Lal A, Mathew J, Jean-St-Michel E, Michels M, Nakano S, Olivotto I, Parent J, Pereira A, Semsarian C, Whitehill R, Wittekind S, Russell M, Conway J, Richmond M, Villa C, Weintraub R, Rossano J, Kantor P,Y. Ho C, Mital S. A validated model for sudden cardiac death risk prediction in pediatric hypertrophic cardiomyopathy. Circulation 2020: 142 (3): pp 217 – 229.
- Ommen SR, Mital S (Vice-Chair), Burke MA, Day SM, Deswal A, Elliott P, Evanovich LL, Hung J, Joglar JA, Kantor P, Kimmelstiel C, Kittleson M, Link MS, Maron MS, Martinez MW, Miyake CY, Schaff HV, Semsarian C, Sorajja P. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2020: 76 (25): pp e159 – e240.
- Shaddy RE, Cetta F, Feltes TF, Penny DJ, Mital S. Moss and Adams’ Heart Disease in Infants, Children and Adolescents, 10th Edition. Vol 1: pp 1 – 982, Vol 2: pp 983 – 1823.
- Turki SA*, Manickaraj AK*, Mercer CL*, Gerety S*, Hitz M-P, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt A-K, Breckpot J, Low J, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer H-H, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O’Kelly IM, Salmon AP, Bu’Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klassen S, Bhattacharya S, DeVriendt K, FitzPatrick D, UK10K, Wilson DI, Mital S†, Hurles ME†.. Rare variants in NR2F2 cause congenital heart defects in humans. Amer J Human Genetics. 2014. 94 (4): pp 574 – 578. (* Co-first authors; † Co-corresponding authors).
- 2022–2028: Brain injury and dysmaturation in newborns with congenital heart disease born preterm. NIH RO1. Principal Investigator: McQuillen P. Co-Investigators: Miller S, Seed M, Mital S.
- 2022–2025: Implementing a Sudden cardiac death Risk assessment Tool in childhood hypertrophic cardiomyopathy (INSERT-HCM). CIHR Project Grant (PJT 183820). Principal Investigator: Mital S. Co-PI: Barwick, M.
- 2022–2027: Canadian Heart Function Alliance. CIHR Network Grant (HFN 181992). Principal Invesitigators: Rouleau J, Bains M. Co-Investigator and Paediatric Co-Lead: Mital S, Jeewa A, Anthony S.
- 2021–2026: A role for novel regulatory variants in childhood cardiomyopathy. CIHR Project Grant (PJT 175034). Principal Investigators: Mital S, Ellis J.
- 2019–2024: PeRsOnalized Genomics for CongEniTal HEart Disease (PROCEED), In partnership with German Federal Ministry of Research and Education and the Netherlands Organization for Health Research and Development. CIHR ERA PerMed Joint Transnational Call. Nomiated Principal Investigator: Mital S, Co- Principal Investigators: Bezzina C, Post M, Hitz MP, Fiume M.
Relevant pages
- September 21, 2023: Toronto Star – "He had the potential to change the world: How Nathan's story highlights future patient care at SickKids"
- September 18, 2023: Podcast, Café Scientique, CGEn Café Scientifique – Breaking down barriers: Exploring the role of equity in the future of precision medicine
- May 3, 2022: SickKids joins new Canadian Heart Function Alliance to help improve health outcomes for Canadians living with heart failure
- February 14, 2022: Researchers show whole genome sequencing can identify hidden changes in genomes of patients with cardiomyopathy
- November 25, 2021: ABC News – How an NBA player’s genetic heart disease led to advocacy for hypertrophic cardiomyopathy
- September 24, 2021: CTV Toronto – Evening news story on sudden death risk prediction calculator
- November 23, 2020: New HCM guidelines make shared decision-making top priority
- May 18, 2020: New tool to help doctors better prevent sudden cardiac death in children
- February 12, 2020: How genomics research can impact families in real time
- August 23, 2019: Why we must screen early in life for hypertrophic cardiomyopathy
- April 12, 2019: Trans-Atlantic partnership seeks answers for cyanotic heart disease, Seema Mital