Joerg Krueger

Medical Director, CAR T-Cell Program

Dr. Krueger joined the Division of Haematology/Oncology in 2015. He is a Project Investigator at SickKids Research Institute and an Assistant Professor in the Faculty of Medicine at the University of Toronto. Dr. Krueger obtained his medical and research training at the Philips University in Marburg, Germany and Humboldt University in Berlin, Germany. He completed his paediatric residency at the Charité University Hospital in Berlin and a Clinical Fellowship in Haematology and Oncology at SickKids. Dr. Krueger did his doctoral thesis at the Humboldt University and completed a Postdoctoral Fellowship at the Scripps Research Institute in La Jolla, California, with a research focus on immune therapeutic approaches to cancers.

Education

• 2013–2015: Clinical Associate, Research Fellow, Blood and Marrow Transplant/Cellular Therapy, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON 
• 2011–2013: Clinical Fellow, Blood and Marrow Transplant / Cellular Therapy, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON
• 2010–2011: Pediatrician, Department of General Pediatrics, Hepatology and Gastroenterology, Radiology, Charité Hospital, Berlin, Germany
• 2006–2010: Resident in Pediatrics, Department of Pediatrics, Charité Hospital, Berlin, Germany 
• 2002–2006: Postdoctoral Fellow, Research of T-cell vaccinations in mouse tumor models and tumor stem cells in solid tumors, Laboratory of Prof. R. Reisfeld, The Scripps Research Institute, La Jolla, CA, USA
• 2000–2002: Resident in Pediatrics, Charité Hospital, Department of Pediatrics, Berlin, Germany
• 1999-2000: Doctoral Thesis, Humboldt University, Berlin, Germany: Molecular synthesis and characterization of human antibodies for immunotherapy of GD2 positive tumors
• 1999: M.D., Humboldt University Berlin, Germany

Experience

• 2015–Present: Staff Physician, Blood and Marrow Transplant/Cellular Therapy, Division of Haematology/Oncology, The Hospital for Sick Children
• 2015–Present:  Project Investigator, Research Institute, The Hospital for Sick Children 
• 2015–Present: Assistant Professor, Faculty of Medicine, University of Toronto 

Research

Dr. Krueger’s current research focuses on cellular therapies and immunological tolerance. Specifically, Dr. Krueger’s research focuses on cellular therapeutic approaches to cancer, including a) CAR T-cells for the treatment of acute lymphoblastic leukemia (ALL); he oversees the CAR T-cell trials for patients with acute leukemias and non-Hodgkin lymphomas, as well as treatments with cytotoxic T-cell (CTLs) for patients with Post Transplant Lymphoproliferative Diseases (PTLD) at SickKids. b) Stimulation of NK cells to treat rare brain tumors in children. Dr. Krueger’s research also focuses on techniques for collection of immune effector and hematopoietic stem cells (Apheresis); mechanisms of tolerance in patients with mixed chimeras after allogeneic stem cell transplant and stem cell transplant approaches for patients with hemophagocytic lymphohistiocytosis (HLH).

See a full list of Joerg Krueger's publications

Funding

• Canada First Research Excellence Fund (CFREF) 
• Garron Family Cancer Centre (GFCC) 
• Canadian National Transplant Research Program (CNTRP)
• Bone Health Centre