Mark Henkelman

Dr. R. Mark Henkelman is a Professor in the Departments of Medical Biophysics and Medical Imaging at the University of Toronto. He is a Senior Scientist Emeritus and Founder of the Mouse Imaging Centre (MICe) at SickKids Research Institute and his latest appointment, Officer of the Order of Canada.

Dr. Henkelman is a co-author on over 400 publications, 660 abstracts and numerous presentations worldwide. He holds a Tier 1 Canada Research Chair in Imaging. In 1998, he was awarded a Gold Medal from the International Society of Magnetic Resonance in Medicine. In 2005, he was appointed a Fellow of the Royal Society of Canada and a University Professor, the highest honor that the University of Toronto awards to its faculty. In 2010, he was awarded the Killam Prize in Health Sciences by the Canada Council for the Arts.

Research

Dr. Henkelman’s research is focused on the Mouse Imaging Centre (MICe), which incorporates high-field magnetic resonance imaging microscopy, ultrasound biomicroscopy, micro computed tomography, and several optical techniques.

Using these imaging tools, MICe screens genetically-modified mice to look for phenotypes that represent human diseases, and also takes established mouse models of human disease and uses imaging to follow the progression of disease and response to treatment over time.

Education

• 1969: B.Sc. Hon., Theoretical Physics, University of Toronto, Toronto, Ontario, Canada
• 1970: M.Sc., Theoretical Physics, McMaster University, Hamilton, Ontario, Canada
• 1973: PhD, Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Experience

• 1973–1979: Staff Biophysicist, B.C. Cancer Foundation, Vancouver, British Columbia, Canada
• 1975–1979: Honorary Lecturer, Department of Physics, University of British Columbia, Vancouver, British Columbia, Canada
• 1979–1984: Associate Professor, Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
• 1979–1989: Staff Physicist, Ontario Cancer Institute, Toronto, Ontario, Canada
• 1982–1990: Associate Chairman, Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
• 1997–1998: Visiting Scholar, Department of Electrical Engineering, Stanford University, Stanford, California, USA
• 1993–1998: Adjunct Professor, Regent College, Vancouver, BC, Canada
• 1989–1999: Vice-President for Research, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada
• 1989–2008: Senior Scientist, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Ontario, Canada
• 1999–2017: Senior Scientist and Director, Mouse Imaging Centre, Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
• 1984–Present: Professor, Depts. of Medical Biophysics & Medical Imaging, University of Toronto, Toronto, Ontario, Canada
• 2017–Present: Senior Scientist Emeritus, Mouse Imaging Centre, Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

Achievements

• 1991: Fellow, Society for Magnetic Resonance Imaging
• 1998: Gold Medal, International Society for Magnetic Resonance in Medicine
• 2001–2016: Canada Research Chair
• 2005: University Professorship
• 2005: Fellow, Royal Society of Canada
• 2005–2006: Acenberg Award, Rotman Research Institute
• 2008: Robert L. Noble Prize, National Cancer Institute of Canada
• 2010: Killam Prize in Health Sciences from the Canada Council
• 2015: Fellow, Canadian Organization of Medical Physicists
• 2019: Officer, Order of Canada

1. R.M. Henkelman, G.J. Stanisz, S.J. Graham. Magnetization Transfer in MRI: A Review.  NMR in Biomedicine 14(2):57-64, 2001.
2. N.A. Bock, N.B. Konyer, R.M. Henkelman.  Multiple-Mouse MRI. Magn. Reson. Med. 49(1):158-167, 2003.
3. M.E. Dickinson, A. Flenniken, M. Bucan, L. Teboul, M.D. Wong,J.K. White, T.F. Meehan, W.J. Weninger, H. Westerberg, H. Adissu, C.N. Baker, L. Bower, J.M. Brown, L.B. Caddle, F. Chiani, D. Clary, J. Cleak…R.M Henkelman et. al.  High-throughput discovery of novel developmental phenotypes.  Nature 537(7621): 508-514, 2016.
4. Ellegood, E. Anagnostou, B.A. Babineau, J.N. Crawley, L. Lin, M.Genestine, E. DiCicco-Bloom, J.K. Lai, J.A. Foster, O.Peñagarikano, D.H. Geschwind, L.K. Pacey, D.R. Hampson, C.L. Laliberté, A.A. Mills, E. Tam, L.R. Osborne, M. Kouser, F. Espinosa-Becerra, Z. Xuan, C.M. Powell, A. Raznahan, D.M. Robins, N. Nakai, J. Nakatani, T. Takumi, M.C. van Eede, T.M. Kerr, C. Muller, R.D. Blakely, J. Veenstra-VanderWeele, R.M. Henkelman, J.P. Lerch.  Clustering Autism: Using Neuroanatomical Differences in 26 Mouse Models Related to Autism to Gain Insight into the Heterogeneity. Molecular Psychiatry 20(1):188-25, 2015.

Funding

• 2015–2022: Imaging of Normal and Abnormal Brain Development in Mice and Humans. Canadian Institutes of Health Research-Foundation 
  J.P. Lerch, R.M. Henkelman
• 2017–2022: MRI of the mouse: linking structure, function, and disease. 
  Canada Foundation for Innovation – Innovation Grant 
  J.G. Sled (PI), J. Foster, M. Henkelman, J. Lerch, C. McKerlie, B. Nieman, J. Rossant, M. Salter, S. Scherer 
• 2017–2022: Establishment and Characterization of Novel Mutant Mouse Models for the Addiction Research Community. National Institutes of Health. V. Kumar, R.M Henkelman, B.J. Nieman