Eric Campos

Dr. Campos has a keen interest in epigenetics and chromatin biology. He obtained his doctoral degree from the University of British Columbia, after which he embarked on a postdoctoral position under the guidance of Dr. Danny Reinberg at the New York University School of Medicine. He joined SickKids Research Institute in 2015, where his team is now studying histone proteins and their chaperones.

Research

The Campos Lab aims to understand the molecular pathways by which histone chaperones lead to histone deposition, thereby influencing local chromatin structures. The lab is also examining how these pathways go awry in certain diseases, such as cancer. This is primarily done biochemically (e.g. protein level), and at the cellular level.

Education and experience

• 2015–Present: Scientist, Genetics & Genome Biology program, The Hospital for Sick Children, Toronto, Canada
• 2015–Present: Assistant Professor, Department of Molecular Genetics, University of Toronto, Toronto, Canada
• 2012–2015: Research Associate, Biochemistry & Molecular Pharmacology, NYU School of Medicine, New York University
• 2006–2012: Howard Hughes Medical Institute (HHMI) Postdoctoral Fellow, Biochemistry & Molecular Pharmacology, NYU School of Medicine, New York University

1. Khazaei S, Chen CCL, Andrade AF, Kabir N, Azarafshar P, Morcos SM, França JA, Lopes M, Lund PJ, Danieau G, Worme S, Adnani L, Nzirorera N, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ, Bryant L, Hébert S, Tong B, Sihota TS, Faury D, Puligandla E, Jawhar W, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam B, Gomes CC, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K, Cocanougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI, Kleinman CL, Garzia L, Jabado N. Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. Cell. 2023 Mar 16;186(6):1162-1178.e20. doi: 10.1016/j.cell.2023.02.023. PMID: 36931244; PMCID: PMC10112048.
2. Kerschbamer E, Arnoldi M, Tripathi T, Pellegrini M, Maturi S, Erdin S, Salviato E, Di Leva F, Sebestyén E, Dassi E, Zarantonello G, Benelli M, Campos E, Basson MA, Gusella JF, Gustincich S, Piazza S, Demichelis F, Talkowski ME, Ferrari F, Biagioli M. CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing. Nucleic Acids Res. 2022 Dec 9;50(22):12809-12828. doi: 10.1093/nar/gkac1134. PMID: 36537238; PMCID: PMC9825192.
3. Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio SG, Vadivel Anguraj AK, Lubanszky E, Yun HY, Portante A, Carette S, Zhang C, Moran MF, Raught B, Campos EI, Hawkins C. Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Acta Neuropathol. 2022 Nov;144(5):1027-1048. doi: 10.1007/s00401-022-02489-2. Epub 2022 Sep 7. PMID: 36070144; PMCID: PMC9547787.
4. Siddaway R, Milos S, Coyaud É, Yun HY, Morcos SM, Pajovic S, Campos EI, Raught B, Hawkins C. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Mol Cell Proteomics. 2022 Oct;21(10):100411. doi: 10.1016/j.mcpro.2022.100411. Epub 2022 Sep 9. PMID: 36089195; PMCID: PMC9540345.
5. McQuaid ME, Ahmed K, Tran S, Rousseau J, Shaheen R, Kernohan KD, Yuki KE, Grover P, Dreseris ES, Ahmed S, Dupuis L, Stimec J, Shago M, Al-Hassnan ZN, Tremblay R, Maass PG, Wilson MD, Grunebaum E, Boycott KM, Boisvert FM, Maddirevula S, Faqeih EA, Almanjomi F, Khan ZU, Alkuraya FS, Campeau PM, Kannu P, Campos EI, Wurtele H. Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome. JCI Insight. 2022 May 23;7(10):e155648. doi: 10.1172/jci.insight.155648. PMID: 35603789; PMCID: PMC9215265.

See a full list of Dr. Campos' publications on PubMed and Google Scholar.