Eric Campos

Dr. Campos has a keen interest in epigenetics and chromatin biology. He obtained his doctoral degree from the University of British Columbia, after which he embarked on a postdoctoral position under the guidance of Dr. Danny Reinberg at the New York University School of Medicine. He joined SickKids Research Institute in 2015, where his team is now studying histone proteins and their chaperones.

Research

The Campos Lab aims to understand the molecular pathways by which histone chaperones lead to histone deposition, thereby influencing local chromatin structures. The lab is also examining how these pathways go awry in certain diseases, such as cancer. This is primarily done biochemically (e.g. protein level), and at the cellular level.

Education and experience

• 2024–Present: Senior Scientist, Genetics & Genome Biology program, The Hospital for Sick Children, Toronto, Canada
• 2023–Present: Associate Professor, Department of Molecular Genetics, University of Toronto, Toronto, Canada
• 2015–2024: Scientist, Genetics & Genome Biology program, The Hospital for Sick Children, Toronto, Canada
• 2015–2023: Assistant Professor, Department of Molecular Genetics, University of Toronto, Toronto, Canada
• 2012–2015: Research Associate, Biochemistry & Molecular Pharmacology, NYU School of Medicine, New York University
• 2006–2012: Howard Hughes Medical Institute (HHMI) Postdoctoral Fellow, Biochemistry & Molecular Pharmacology, NYU School of Medicine, New York University

1. Jurkovic CM, Raisch J, Tran S, Nguyen HD, Lévesque D, Scott MS, Campos EI*, Boisvert FM*. (2024) Replisome Proximal Protein Associations and Dynamic Proteomic Changes at Stalled Replication Forks. Mol Cell Proteomics, 23(5), 100767. doi: 10.1016/j.mcpro.2024.100767. PMID: 38615877; PMCID: PMC11101681
2. Khazaei S, Chen CCL, Andrade AF, Kabir N, Azarafshar P, Morcos SM, França JA, Lopes M, Lund PJ, Danieau G, Worme S, Adnani L, Nzirorera N, Chen X, Yogarajah G, Russo C, Zeinieh M, Wong CJ, Bryant L, Hébert S, Tong B, Sihota TS, Faury D, Puligandla E, Jawhar W, Sandy V, Cowan M, Nakada EM, Jerome-Majewska LA, Ellezam B, Gomes CC, Denecke J, Lessel D, McDonald MT, Pizoli CE, Taylor K, Cocanougher BT, Bhoj EJ, Gingras AC, Garcia BA, Lu C, Campos EI, Kleinman CL, Garzia L, Jabado N. (2023) Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration. Cell. 186(6):1162-1178.e20. doi: 10.1016/j.cell.2023.02.023. PMID: 36931244; PMCID: PMC10112048.
3. Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio SG, Vadivel Anguraj AK, Lubanszky E, Yun HY, Portante A, Carette S, Zhang C, Moran MF, Raught B, Campos EI, Hawkins C. (2022) Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Acta Neuropathol, 144(5):1027-1048. doi: 10.1007/s00401-022-02489-2. Epub 2022 Sep 7. PMID: 36070144; PMCID: PMC9547787.
4. McQuaid ME, Ahmed K, Tran S, Rousseau J, Shaheen R, Kernohan KD, Yuki KE, Grover P, Dreseris ES, Ahmed S, Dupuis L, Stimec J, Shago M, Al-Hassnan ZN, Tremblay R, Maass PG, Wilson MD, Grunebaum E, Boycott KM, Boisvert FM, Maddirevula S, Faqeih EA, Almanjomi F, Khan ZU, Alkuraya FS, Campeau PM*, Kannu P*, Campos EI*, Wurtele H*. (2022) Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome. JCI Insight, 7(10):e155648. doi: 10.1172/jci.insight.155648. PMID: 35603789; PMCID: PMC9215265.
5. Scott WA, Dhanji EZ, Dyakov BJA, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras AC, Campos EI. (2021) ATRX proximal protein associations boast roles beyond histone deposition. PLoS Genet, 17(11):e1009909. doi: 10.1371/journal.pgen.1009909. PMID: 34780483; PMCID: PMC8629390

See a full list of Dr. Campos' publications on PubMed and Google Scholar.