Hyperoxaluria Panel (Currently not available)

Alternate test name

Panel includes Glycolic acid, Oxalic acid, Glyceric acid and Glyoxylic acid

Lab area

Clinical Biochemistry - Metabolic Diseases

Method and equipment

Stable isotope dilution Gas Chromatography - Mass Spectrometry (GC-MS)

Expected turn-around time

3 weeks

Specimen type

Urine

Specimen requirements

1 mL of urine in sterile screw top container

Storage and transportation

Samples may be refrigerated or remain at room temperature for up to 12 hours.

Samples stored for more than 12 hours or being transported from external sites should be frozen (-20 degrees).

Special requirements

Cautions: Ascorbic acid will falsely increase oxalic acid results.

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Hyperoxaluria Panel (Currently not available) - requisition

Background and clinical significance

This test is useful for the identification of hyperoxaluria, a condition that may result in kidney stone formation, nephrocalcinosis, progressive kidney damage and systemic calcium oxalate deposition. Primary hyperoxaluria is a group of inherited metabolic disorders affecting glyoxylate metabolishm (types I, II, and III) that may be differentiated by respective elevations in glycolic acid, glyceric acid and glyoxylic acid.

Disease condition

Primary hyperoxaluria type I (PH I), primary hyperoxaluria type II (PH II), and primary hyperoxaluria type III (PH III)