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Gentamicin, plasma or serum

Lab area
Clinical Biochemistry - TDM & Toxicology
Method and equipment
Vitros 5600
Expected turn-around time
Stat: 1 hour Urgent/ Routine: 2 hours
Specimen type

Serum, Plasma (Heparin)

Specimen requirements

150 uL

Storage and transportation

4°C (transport with a cool pack if possible)

Shipping information
The Hospital for Sick Children
Rapid Response Laboratory
555 University Avenue, Room 3642
Toronto, ON
M5G 1X8
Phone: 416-813-7200
Toll Free: 1-855-381-3212
Hours: 7 days/week, 24 hours/day
Background and clinical significance

Gentamicin and other aminoglycosides are potentially nephrotoxic. The risk of nephrotoxicity is greater in patients with impaired renal function and in those who receive high dosage or prolonged therapy. Neurotoxicity can occur in patients treated with gentamicin with or without preexisting renal damage. Aminoglycoside-induced neurotoxicity is usually irreversible. Gentamicin use is mainly restricted to the therapy of life-threatening infections and those for which a less toxic antimicrobial agent is ineffective. It is frequently used for the treatment of serious infections; particularly those due to Pseudomona aeruginosa, Enterobacter, Klebsiella, Serratia, Citrobacter, Staphylococcus, and other species. Measurement of gentamicin is used to monitor the serum concentration to assure adequate levels and to avoid potential toxic levels.

Disease condition


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