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Hereditary Hearing Loss: Common and Non-Syndromic Hearing Loss Panel

Alternate test name

HHL: Common and Non-Syndromic Hearing Loss Panel

Gene name / Alternate gene name
  • ACTG1
  • ADGRV1
  • CDH23
  • CHD7
  • CLDN14
  • COCH
  • DFNA5
  • DFNB59
  • DIAPH1
  • ESPN
  • EYA1
  • EYA4
  • GJB2
  • GJB6
  • GIPC3
  • GPSM2
  • GRHL2
  • GRXCR1
  • HGF
  • ILDR1
  • KCNQ1
  • KCNQ4
  • KCNE1
  • LHFPL5
  • LOXHD1
  • MYH14
  • MYH9
  • MYO15A
  • MYO3A
  • MYO6
  • MYO7A
  • OTOA
  • OTOF
  • OTOG
  • PCDH15
  • POU3F4
  • POU4F3
  • PRPS1
  • RDX
  • SIX1
  • SLC17A8
  • SLC26A4
  • SMPX
  • STRC
  • TMC1
  • TMIE
  • TPRN
  • USH2A
  • WFS1

Alternate Gene Name

ACTG, DFNA20, DFNA26, DFNB12, USH1D, CDHR23, CRG, KIAA1416, FLJ20357, FLJ20361, DFNB29, DFNA31, DFNA9, COCH-5B2, ICERE-1, pejvakin, DFNA1, hDIA1, LFHL1, DFNB36, ESRL2, DFNB35, ERR2, ERRbeta, NR3B2, ERRb, BOR, DFNA10, CMD1J, DFNB1, DFNA3, CX26, NSRD1, DFNA2, DFNA3, ED2, EDH, HED, CX30, DFNB82, LGN, Pins, DFNA28, TFCP2L3, FLJ13782, BOM, DFNB25, DFNB39, SF, F-TCF, HGFB, HPTA, DFNA2, Kv7.4, DFNB67, MGC33835, dJ510O8.8, Tmhs, DFNB77, FLJ32670, LH2D1, LRRC51, DFNB63, COMT2, MRVLDC2, DFNB49, FLJ30532, TRIC, DFNA4, FLJ13881, KIAA2034, MHC16, MYH17, DFNA17, NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, DFNB3, MYO15, DFNB30, DFNA22, DFNB37, KIAA0389, DFNB22, CT108, DFNB9, FER1L2, DFNB6, DFN3, BRN4, OTF9, DFNX2, DFNA15, BRN3C, DFN2, CMTX5, DFNX1, DFNB24, PI6, DFNB91, PTI, CAP, DFNA23, DFNA25, VGLUT3, DFNB4, PDS, DFN6, DFNX4, DFNB16, DFNA12, DFNA8, DFNB21, DFNA36, DFNB7, DFNB11, DFNB6, DFNB10, DFNB8, C9orf75, DFNB79, FLJ90254, DFNB28, HRIHFB2122, KIAA1662, Tara, DFNA6, DFNA14, DFNA38, DIDMOAD, WFS, DFNB23, USH1F, CDHR15, DFNB42, MGC50831, C19orf64, DFNB15, DFNB72, DFNB95, MASS1, KIAA0686, USH2C, GPR98, DFNA11, DFNB2, USH1B, KVLQT1, JLNS1, MINK, JLNS2, OTGN, DFNB18B, C12ORF64, DFNB84B, PTPGMC1, DFNA73, DFNB84A

Lab area
Genome Diagnostics - Molecular Genetics
Method and equipment
All genes are sequenced by Next Generation Sequencing. STRC dosage analysis is carried out (by MLPA) when the Common and Non-syndromic Hearing Loss NGS Panel is requested. Deletion & duplication analysis by exon targeted microarray is also available for all other genes on this panel by request on the requisition. 
Expected turn-around time
Prenatal samples/Pregnancy/STAT: 2 weeks Routine: 6 weeks
Specimen type

Blood; please contact the Genome Diagnostics Laboratory if you want to send gDNA. If sending a prenatal sample, please contact the laboratory prior to sending sample to discuss sample requirements.

For details about specimen requirements, please refer to: Specimen Types & Requirements (PDF).

Specimen requirements
  • Blood: 5-10 mL in EDTA, 0.5 mL in EDTA (neonate); 
  • DNA-minimum 10 ug in 100 uL low TE (pH8.0)
Storage and transportation

Blood-Room Temperature. Please contact the Genome Diagnostics Laboratory if you want to send gDNA.

If sample shipment  >48 hours, ship on ice.

DNA extracted at an external lab is not accepted for MLPA testing.

Special requirements

Special Instructions for Genome Diagnostics Samples

Please ship us the blood sample within 48 hours of collection.

Shipping information
The Hospital for Sick Children
Division of Genome Diagnostics
555 University Avenue, Black Wing, Room 3416
Toronto, ON
M5G 1X8
Phone: 416-813-7200 ext. 2
Hours: Monday to Friday, 8 a.m. to 4:30 p.m.
Off hours: Please send to Rapid Response Laboratory, 555 University Avenue, Room 3642
Email Molecular Lab:
Email Cytogenetics:
Disease condition

Common and non-syndromic hearing loss

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