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SickKids

Blayne Amir Sayed

Title: Staff Surgeon, Division of General & Thoracic Surgery
Designations: MD, PhD
Phone: 416-813-7654 ext. 206401
Fax: 416-813-7477
Alternate Contact Name: Shannon Hannah
Alternate Phone: 416-813-7654 ext. 206401
Alternate Email: shannon.hannah@sickkids.ca
U of T Positions: Assistant Professor, Department of Surgery

Research Positions

Associate Scientist Track
Cell Biology

Biography

Dr. Sayed is a member of the Division of General & Thoracic Surgery at SickKids. He specializes in malignant and benign diseases of the liver and biliary tract. Dr. Sayed is dually certified in hepatopancreatobiliary surgery and abdominal organ transplantation with particular interests in minimally invasive liver surgery, living donor liver transplantation and complex liver surgery involving vascular and biliary reconstruction. Dr. Sayed is an Associate Scientist Track with a background in cellular immunology. He is building a lab focused on understanding the molecular machinery controlling the development of immunologic memory following solid organ transplantation. 

Research

Dr. Sayed is an Associate Scientist Track with a background in cellular immunology. His research is focused on understanding the molecular machinery controlling the development of allo-immunity following solid organ transplantation. This includes an interest in the epigenetic mechanisms of memory formation in cells of both the adaptive and innate immune systems. Dr. Sayed is a member of the Cell Biology program and his mentor is Dr. Sergio Grinstein.

Education and experience

  • 2017–2019: Clinical Fellow, Abdominal Organ Transplantation and Hepatopancreatobiliary Surgery, Department of Surgery, University of Toronto, Toronto, ON CA
  • 2016–2017: Administrative Chief Resident, Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2014–2015: Clinical Fellow, Liver Transplant Unit and Liver Sciences Institute, King’s College Hospital and King’s College London, London, U.K.
  • 2011–2017: General Surgery Resident, Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2002–2011: NIH Medical Scientist Training Program (MSTP), Northwestern University Feinberg School of Medicine, Chicago, IL
  • 2011: MD, Northwestern University Feinberg School of Medicine, Chicago, IL
  • 2009: PhD, Integrated Graduate Program (IGP), Department of Microbiology & Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL
  • 1998-2001: BA with distinction, University of Virginia, Charlottesville, VA 

Achievements

  • 2019: American Society of Transplantation (AST) Liver & Intestinal Community of Practice (LICOP) Travel Award, American Transplant Congress, Boston MA
  • 2017: Douglas A Murray Professionalism in Surgery Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2017: David V Feliciano Resident Excellence in Teaching Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2016–2017: Administrative Chief Resident (elect), Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2014: J.D. Martin Surgical Resident Award, Department of Surgery, Emory University School of Medicine, Atlanta, GA
  • 2010: Alpha Omega Alpha (AOA) Honor Medical Society, Gamma Illinois Chapter, Feinberg School of Medicine, Northwestern University, Chicago, IL.
  • 2009–2010: Alliance for Graduate Education and the Professoriate (AGEP) Scholar, The Graduate School, Northwestern University, Evanston, IL.
  • 2009–2010: Herbert W. Nickens Medical Student Award, Association of American Medical Colleges (AAMC), Washington, DC.

Publications

  1. BP Lovasik, PR Rajdev, SC Kim, JK Srinivasan, WL Ingram, BA Sayed. “The Living Monument”: The Desegregation of Grady Memorial Hospital and the Changing South. Am Surgeon. 2020 Mar 1; 86(3):213-219. 
  2. N Goldaracena, BA Sayed, MC Cattral. Caval replacement with cadaveric external iIliac vein in pediatric liver transplant: Internal iliac vein as optimal site for outflow anastomosis. Liver Transpl. 2019 Mar 10.
  3. S Amaral, BA Sayed, N Kutner, RE Patzer. Preemptive kidney transplantation is associated with survival benefits among pediatric patients with end-stage renal disease. Kidney Int. 2016 Nov;90(5):1100-1108.
  4. BA Sayed, AL Christy, ME Walker and MA Brown. (2010) Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment? J Immunol. Jun 15;184(12):6891-900.
  5. BA Sayed, ME Walker and MA Brown. (2011) Cutting edge: Mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis. J Immunol. Mar 15;186(6):3294-8.

  • 2020–2021: HSBC Catalyst Research Grant, SickKids. Personalized physiologic phenotyping in the ICU to predict clinical outcomes in liver transplant patients. Co-investigator
  •  2015–2017: Translational Science Fellowship Research Grant, American Society of Transplantation (AST). Epigenetic regulation of CTLA-4 modifies susceptibility to the development of pathogenic T cells mediating a belatacept resistant alloreactive immune response  Principal Investigator 
  • 2011: Genentech Presidential Student Mentorship Grant, American Society of Transplant Surgeons.The role of short lived effector cells (SLEC) in the alloimmune response. Principal Investigator
  • 2005–2010: Kirschtein National Research Service Award (NRSA), Individual Pre-doctoral Fellowship: Blayne Amir Sayed. Natl. Inst. for Neurological Disease and Stroke (NINDS), NIH: F31 NS054395-01.The role of mast cells in a model of relapsing remitting multiple sclerosis. Principal Investigator 
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