Cecil Robert Pace-Asciak

Dr. Cecil Robert Pace-Asciak is a senior member of the Translational Medicine program. He has been involved in lipid research throughout his career, discovering first the changes in prostaglandin synthesis and metabolism LOX derived hepoxilins, and their metabolites and their synthetic analogs.

Currently, he’s studying the isolation of novel lipids released from the skin of catfish from the Gulf region.

Education and experience

• 1962–1965: PhD, Organic Chemistry, McGill, Montreal, QC
• 1965–1972: Postdoctoral fellow, Montreal Neurological Institute
• 1972–1977: Scientist, SickKids Research Institute, and Assistant Professor, Pharmacology, University of Toronto, Toronto, ON
• 1977–1984: Associate Professor, Pharmacology, University of Toronto, Toronto, ON
• 1984–2005: Senior Scientist, SickKids Research Institute, and Professor, Pharmacology, University of Toronto, Toronto, ON
• 2005–Present: Senior Scientist Emeritus, SickKids Research Institute and Professor Emeritus, Pharmacology, University of Toronto, Toronto, ON

Achievements

• 1980-81: Josiah Macy Jr. Foundation Faculty Scholarship Award (Sabbatical leave)

1. Pace-Asciak, C. R., Granström, E. and Samuelsson, B. Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12and 10,11,12-trihydroxyeicosatrienoic acids. J. Biol. Chem. 258: 6835-6840, 1983.
2. Pace-Asciak, C. R. and Martin, J. M. Hepoxilin, a new family of insulin secretagogues formed by intact rat pancreatic islets. Prostaglandins, Leukotrienes and Medicine 16: 173-180, 1984.
3. Khan MA, Pace-Asciak C, Al-Hassan JM, Afzal M, Liu YF, Oommen S, Paul BM, Nair D, Palaniyar N. Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils. Biomolecules. 2018 Nov 13;8(4). (Q1 (JCR); IF=4.69)
4. Al-Hassan JM, Fang Liu Y, Khan MA, Yang P, Guan R, Wen XY, Afzal M, Oommen S, Paul BM, Nair D, Palaniyar N, Pace-Asciak, C* . Furanoic Lipid F-6, A Novel Anti- Cancer Compound that Kills Cancer Cells by Suppressing Proliferation and Inducing Apoptosis. Cancers (Basel). 2019 Jul 9;11(7). (Q1 (JCR); IF=6.16)
5. Jassim M. Al-Hassan, Aleksander Hinek, Waleed M. Renno, Yanting Wang2, Yuan Fang Liu, Rui Guan, Xiao-Yen Wen4, Michael L. Litvack, Andras Lindenmaier, Mohammad Afzal, Bincy Paul, Sosamma Oommen, Divya Nair, Jijin Kumar, Meraj A. Khan, Nades Palaniyar and Cecil Pace-Asciak *. Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish: A Unique Furan Fatty Acid (F6) and Cholesta-3,5-Diene (S5) Recruit Neutrophils and Fibroblasts to Promote Wound Healing.