Genomic SNP Microarray - Blood

Alternate test name

Lab area

Genome Diagnostics - Cytogenetics

Method and equipment

DNA extraction; Genomic Microarray Platform - Cytoscan HD SNP Array (Affymetrix)

Expected turn-around time

Newborns and expedited cases: 2-3 weeks Routine: 4-6 weeks

Specimen type

Peripheral blood

Genomic DNA

Specimen requirements

1-3 mL (0.5 mL) minimum for neonates; 6 mL for adults

DNA; 1µg at ≥50ng/µl minimum from an accredited laboratory

Storage and transportation

Maintain at room temperature. Do not refrigerate or freeze.

Please note: A completed SickKids Genomic SNP Microarray requistion is required.

The reasons for referral listed on the submitted microarray requistion MUST meet the indications authorized by the MOHLTC, which include developmental delay/intellectual disability and/or multiple congenital anomalies.

Special requirements

Collect in EDTA tube

DNA; 1µg at ≥50ng/µl minimum from an accredited laboratory

Shipping information

The Hospital for Sick Children

Division of Genome Diagnostics

555 University Avenue, Black Wing, Room 3416

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200 ext. 2

Hours: Monday to Friday, 8 a.m. to 4:30 p.m.

Off hours: Please send to Rapid Response Laboratory, 555 University Avenue, Room 3642

Email Molecular Lab: molecular.lab@sickkids.ca

Email Cytogenetics: cytogenetics.requests@sickkids.ca

Requisition

Genomic SNP Microarray - Blood - requisition

Background and clinical significance

Approximately 10-20% of individuals with unexplained developmental delay or multiple congenital anomalies will have a CNV considered to be clinically relevant.

Disease condition

Developmental delay and or multiple congenital anomalies