Carbamazepine-10,11-Epoxide

Alternate test name

Lab area

Clinical Biochemistry - TDM & Toxicology

Method and equipment

HPLC

Expected turn-around time

Stat: 3 hours Routine: 72 hours

Specimen type

Serum

Plasma (Heparin or Citrate)

Specimen requirements

100 uL

Storage and transportation

Plasma/serum must be separated within 2 hours of collection
Store and ship frozen

Shipping information

The Hospital for Sick Children

Rapid Response Laboratory

555 University Avenue, Room 3642

Toronto, ON

Canada

M5G 1X8

Phone: 416-813-7200

Toll Free: 1-855-381-3212

Hours: 7 days/week, 24 hours/day

Requisition

Carbamazepine-10,11-Epoxide - requisition

Background and clinical significance

Carbamazepine-10,11-epoxide has anticonvulsant activity similar to that of its parent compound, Carbamazepine. The half-life averages six hours. This heterocyclic (iminostilbene) compound has potent antiepileptic properties and is effective alone or with other antiepileptic drugs in controlling many types of seizures. Side effects may include: leukopenia and hyponatremia. Patients in the first month of pregnancy are at increased risk of neural tube defects.

Disease condition

Anticonvulsant