Bone Marrow Transplant Testing (BMT)
Engraftment, BMT Monitoring
Blood; gDNA; bone marrow aspirate
For details about specimen requirements, please refer to: Specimen Type & Requirements.
- Blood: 5-10 mL in EDTA, 0.5 mL in EDTA (neonate);
- DNA-minimum 10 ug in 100 uL low TE (pH8.0)
For details about specimen requirements, please refer to: Specimen Type and Requirements
Bone marrow transplantation is an important adjunct to therapy in a number of hematologic, oncologic and genetic/metabolic disorders. Following a bone marrow transplant or peripheral blood transfusion, patient hematopoietic and lymphoid cells are replaced by cells derived from the donor. The percentage of donor versus host cells is indicative of the success of the engraftment, and can be used to track, or characterize, the engraftment process. In order to define the percentage of cells from two different individuals, host and donor cells must be distinguished from each other. This is done by DNA fingerprinting. This analysis requires three specimens: 1) a source of DNA from the recipient before transplantation; 2) a source of DNA from the donor; and 3) a source of DNA from the recipient after transplantation (blood or bone marrow).
See related information sheet: Bone Marrow Transplant Testing (BMT)
Bone Marrow Transplant
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