Developmental & Stem Cell Biology
We're pushing the boundaries of stem cell biology. We're focused on understanding molecular genetic mechanisms affecting embryonic development, organ formation, tissue homeostasis and regeneration.
The Developmental & Stem Cell Biology program is making an impact on paediatric health-care by translating our research into treatments for associated developmental disorders like childhood cancer, birth defects, and other paediatric diseases. We continue to develop new therapeutic approaches for children and youth through a better grasp of developmental genetics, genomics, and stem cell biology.
Program head Dr. Brian Ciruna and the scientists that lead DSCB labs and core facilities are supported by over 225 graduate students, postdoctoral fellows, research associates, technicians, and administrative staff.
You'll find our lab work regularly published in top peer-reviewed medical and scientific journals. Our scientists and trainees receive consistent funding from the Natural Sciences and Engineering Research Council of Canada (NSERC), Canadian Institutes of Health Research (CIHR), March of Dimes Foundation, Canada Research Chairs, NIH, Genome Canada, Canada Foundation for Innovation, and several other national and international organizations, illustrating the importance and impact of DSCB research.
We always welcome new trainees and staff that are eager to improve the health outcomes of children through cutting-edge biomedical research.
- Dr. Herman Yeger
- Dr. Ben Alman
- Dr. Rodrigo Fernandez-Gonzalez
Dr. Najeeb Siddiqui
- Iris Biberstein
- Nahed Mojadiddi
- Tirhas Okubazghi
- Alicia Campbell
- Maryam Shafiq
- Jody Hayer
November 1, 2022
Researchers have uncovered the mechanics of the blood-tumour barrier in a giant step towards treating medulloblastoma.
September 22, 2022
In the largest study of its kind, SickKids researchers have described the natural history of Alagille syndrome, providing a more complete picture of how the liver disease progresses in childhood.
September 21, 2022
An international research team uncovered the first indication that a type of medulloblastoma may be preventable by identifying how and where these tumours develop during human fetal brain development.
Genetic models of human development and disease
We utilize diverse experimental organisms in their research, including C. elegans, D. melanogaster, zebrafish, planaria, and mice. By developing genetic models of numerous human diseases and cancer, we provide an unmatched platform for interrogating pathogenic mechanisms and performing genetic modifier and therapeutic drug screens.
Mechanisms of tissue patterning and organ development
Developmental signaling pathways – including BMP, Hh, FGF, Notch, TGFb, PCP, and Wnt, – play key roles in pattern formation and organogenesis. We examine the roles of these signaling pathways, as well as other regulatory factors in the development of diverse tissues and organs (e.g. blood, bone, brain, heart, gut, kidney, limb, lung, and skin).
Molecular regulation of cell fate decision, cell differentiation and cell death
We aim to answer a fundamental question in developmental biology - How do cells adopt their fate? Our team studies molecular switches that regulate a cell's fate, as well as mechanisms that program cells to die.
Stem cell biology, tissue engineering and regenerative medicine
We study the molecular genetic regulation of stem cell states, including embryonic, induced pluripotent, cancer, and multiple tissue stem cell models. Stem cells offer tremendous potential for repair and/or regeneration of damaged tissues and organs. We unlock how stem cells and organoids can be used in regenerative medicine and tissue engineering, such as spinal cord injury and bladder regeneration.
Centre for Advanced Single Cell Analysis
CASCA provides comprehensive training and expert consultation services to enable researchers to use the Fluidigm Helios Mass Cytometry (CyTOF), Fluidigm Hyperion Imaging Mass Cytometry (IMC) and BD Rhapsody single cell RNA sequencing (scRNA-Seq) platforms.
Flow Cytometry Facility
The FCF provides academic and corporate clients access to state-of-the-art analytical flow cytometers and high-speed cell sorting services. It offers comprehensive training and education as well as expert consultation services to enable users to enhance the scope and quality of their research using the FCF's technology.